Description

Overview:

Biological systems (e.g. cells) can make stochastic transitions between phenotypes (e.g. states of relatively increased or decreased drug resistance). This means that an initially drug-sensitive population can generate relatively drug-resistant subpopulations. This video presents a metronomogram, which is a tool for understanding whether such stochastic transitions can provide an opportunity for therapeutic treatment. Citation: Liao D, Estevez-Salmeron L, and Tlsty TD (2012) "Conceptualizing a tool to optimize therapy based on dynamic heterogeneity," Phys. Biol. 9:065005.

Subject:

Life Science, Mathematics, Physics

Level:

High School, Community College / Lower Division, College / Upper Division, Graduate / Professional, Career / Technical, Adult Education

Material Type:

Lecture Notes

Author:

David Liao

Provider:

Look At Physics

Provider Set:

A Mathematical Way to Think About Biology

Date Added:

10/08/2012